Catalogue number | C108659 |
Chemical name | Yunaconitine |
CAS Number | 70578-24-4 |
Synonyms | 11aH-12,3,6a-Ethanylylidene-7,9-methanonaphth |
Molecular Weight | C35H49NO11 |
Formula | 659.7 |
Purity | 98% |
Physical Description | White powder |
Solvent | Chloroform, Dichloromethane,DMSO |
Storage | Stored at 2-8°C, Protected from air and light, refrigerate or freeze |
Applications | The anti-inflammatory and analgesic actions of Yunaconitine were reported. When given subcutaneously (10-80μg/kg) or orally (50-100 μg/kg) in rats and mice, Yunaconitine inhibited the increased vascular permeability caused byacetic acid and histamine, the leucocyte migratory response induced by injection of 1 % carrageenin 0.1 ml in rat's thoracic cavity, and the swelling of mouse ear caused by xylene and edema of hind paw elicited by carrageenin, fresh egg white or formaldehyde in intact or in adrenalecto-mized rats. Yunaconitine also showed positive effect in the granuloma inhibition test when it was subcutaneously injected, 10 μg/kg for 6 d, or added directly to the cotton-pellet. That Yunaconitine neither reduced the weights of thymus and adrenal in rats nor prolonged the survival time in adrenalectomized rats indicates that the action of YAc does not depend on stimulation of the pituitary-adreal axis.Assayed with writhing and hot plate method, the median analgesic doses (ED50) of Yunaconitine were found tobe 39 and 42 μg/kg in mice, respectively. Yunaconitine was shown to have antithermic effect in pyrexial rats when administered orally at a dose of 50 μg/kg. |
References | 1. Journal of Pharmaceutical Analysis, 2011, 1(1), 57-59. 2. Acta Botanica Yunnanica, 1998, 20(4), 474-478. 3. J. Nat. Prod., 1986, 49(5), 892-900. |
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After Receiving
The packaging of the product may have turned upside down during transportation, resulting in the product adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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