Voclosporin-d4

Catalogue number C262424
Chemical nameVoclosporin-d4
CAS NumberN/A
Synonyms6-[(2S,3R,4R,6E)-3-Hydroxy-4-methyl-2-(methylamino)-6,8-nonadienoic acid]cyclosporin A-d4; ISATX 247-d4; R 1524-d4; trans-ISA 247-d4;
Molecular WeightC63H107D4N11O12
Formula1218.65
Purity98%
Physical DescriptionOff-White Solid
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsLabelled Voclosporin (V678500). A new agent for the treatment of noninfectious uveitis. Uveitis is an inflammatory, putative Th1-mediated autoimmune disease that affects various parts of the eye and is a leading cause of visual loss. Voclosporin, a rationally designed novel calcineurin inhibitor, exhibits a favorable safety profile, a strong correlation between pharmacokinetic and pharmacodynamic response, and a wide therapeutic window. Immunosuppressant.
ReferencesAspeslet, L., et al.: Transplant Proc., 33, 1048 (2001), Cho, M., et al.: Arthritis Rheum., 46, 1202 (2002), Staatz, C., et al.: Clin. Pharmacokinet., 43, 623 (2004),
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Voclosporin-d4
Price(USD)
SizePrice(USD)Discount
.5mg$175.0010% OFF
2.5mg$700.0010% OFF
10mg$2400.0010% OFF
1mg$300.0010% OFF
5mg$1325.0010% OFF
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