U-44069

Catalogue number C261725
Chemical nameU-44069
CAS Number56985-32-1
Synonyms(5Z)-7-[(1S,4R,5S,6R)-5-[(1E,3S)-3-Hydroxy-1-octen-1-yl]-2-oxabicyclo[2.2.1]hept-6-yl]-5-heptenoic Acid; (15S)-Hydroxy-9α,11α-(epoxymethano)prosta-5Z,13E-dienoic Acid; (5Z,9α,11α,13E,15S)-9,11-Epoxymethano-15-hydroxyprosta-5,13-die
Molecular WeightC21H34O4
Formula350.49
Purity98%
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsU-44069 is a stable analog of the endoperoxide PGH2, and a TP receptor agonist. U-44069 stimulates shape change in human platelets without a measurable increase in [Ca2+] with an EC50 of 1.8 nM. U-44069 has an EC50 of 3 µM and 54 nM for platelet aggregation and phosphatidate formation in human platelets, respectively.
ReferencesMiller, D., et al.: J. Biol. Chem., 260, 1006 (1985), Ruan, K., et al.: J. Biol. Chem., 268, 19483 (1993), So, S., et al.: J. Biol. Chem., 278, 10922 (2003), Ruan, K., et al.: Biochemistry, 47, 680 (2008),
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U-44069
Price(USD)
SizePrice(USD)Discount
25mg$5000.0010% OFF
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