Taraxerone

Catalogue number C101782
Chemical nameTaraxerone
CAS Number514-07-8
Synonyms(4aR,6aR,6aS,8aR,12aR,14aR,14bR)-4,4,6a,6a,8a,11,11,14b-octamethyl-2,4a,5,6,8,9,10,12,12a,13,14,14a-dodecahydro-1H-picen-3-one
Molecular WeightC30H48O
Formula424.7
Purity98%
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications

Taraxerone have been reported with different biological activities, such as allelopathic and antifungal.


Taraxerone exhibited weak antiviral activity against herpes simplex virus (type I and II).
The IC50 values of taraxerone were 102.34±1.53 μM and 1,763.81±12.63 μM/mL (Trolox equivalent) by the DPPH and ferric reducing ability of plasma (FRAP) assays, respectively. Taraxerone exhibited comparable antioxidant capacities with butylated hydroxytoluene (BHT) by the DPPH (p=0.117) and FRAP (p= 0.179) assays. The production of inducible nitric oxide in lipopolysaccharide-stimulated murine macrophage was inhibited by taraxerone (IC50=38.49±3.77 μM) via downregulation of inducible nitric oxide synthase (iNOS) expression at the transcriptional level. The inhibitory effect of taraxerone on nitric oxide generation was significantly more effective than that of caffeic acid and/or gallic acid.

References1. J. Mex. Chem. Soc., 2012, 56(2), 105-108.
2. Dhaka Univ. J. Pharm. Sci., 2009, 8(2), 171-172.
3. Food Science and Biotechnology, 2012, 21(2), 485-489.
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Taraxerone
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