| Catalogue number |
C107972 |
| Chemical name | Tanshinone IIA |
| CAS Number | 568-72-9 |
| Synonyms | 1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g]benzofuran-10,11-dione |
| Molecular Weight | C19H18O3 |
| Formula | 294.4 |
| Purity | 98% |
| Physical Description | Red powder |
| Solvent | Chloroform, Dichloromethane,DMSO |
| Storage | Stored at 2-8°C, Protected from air and light, refrigerate or freeze |
| Applications | Tanshinone IIA is one of the most abundant constituents of the root of Salvia miltiorrhiza which exerts antioxidant and anti-inflammatory actions in many experimental disease models, Tanshinone IIA has been widely used for various cardiovascular and cerebrovascular disorders in Asian countries. Tanshinone IIA pretreatment reduces infarct size and improves cardiac dysfunction after I/R injury in diabetic rats. This was accompanied with decreased cardiac apoptosis and inflammation. The possible mechanism responsible for the effects of TSN is associated with the PI3K/Akt-dependent pathway.
Tanshinone IIA might be a novel promising therapeutic agent for oxidative stress injury in neurodegenerative diseases. Tanshinone IIA may improve renal dysfunction associated with chronic kidney disease.
Tanshinone IIA was effective for attenuating the extent of brain edema formation in response to ischemia injury in rats. TIIA has a prominent protective effect against Spinal cord injury (SCI) through inhibiting the inflammatory response and apoptosis in the spinal cord tissue after SCI.
tanshinone IIA prevents cardiac fibroblast proliferation by interfering with the generation of ROS and involves the activation of the eNOS-NO pathway.
Tanshinone IIA pretreatment attenuated the enlargement of cell surface area induced by ISO in cultured cardiomyocytes. The mRNA level of ANP, BNP and β-MHC was obviously elevated in ISO-treated cardiac cells, which was effectively inhibited by Tanshinone IIA. Moreover, we found that Tanshinone IIA pretreatment could prevent the augment of intracellular calcium transient in ISO-treated cardiomyocytes. The further study revealed that Calcineurin, NFATc3, ANP, BNP and β-MHC proteins were upregulated by ISO in ventricular myocytes, and Tanshinone IIA pretreatment significantly attenuate the increased expression of Calcineurin, NFATc3, ANP, BNP and β-MHC proteins. In summary, Tanshinone IIA attenuated cardiomyocyte hypertrophy induced by ISO through inhibiting Calcineurin/NFATc3 pathway, which provides new insights into the pharmacological role and therapeutic mechanism of Tanshinone IIA in heart diseases.
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| References | 1. Phytochemistry, 1985, 24(4), 815-817.
2. J. Med. Chem., 2004, 47(23), 5816-5819.
3. Phytomedicine, 2003, 10(8), 682-685.
4. Archives of Pharmacal Research, 2005, 28(8), 909-913.
5. Am J Chin Med., 2011, 39(2), 381-394.
6. Int. J. Biol. Sci., 2011, 7(3), 383-389.
7. Diabetes Obes Metab., 2010, 12(4), 316-322.
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| Size | Price(USD) | Discount |
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| 10mg | Inquiry | N/A |
| 25mg | Inquiry | N/A |
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