Tanshindiol C

Catalogue number C104802
Chemical nameTanshindiol C
CAS Number97465-71-9
Synonyms(6R)-6,7,8,9-Tetrahydro-6beta,7alpha-dihydroxy-1,6-dimethylphenanthro[1,2-b]furan-10,11-dione
Molecular WeightC18H16O5
Formula312.3
Purity98%
Physical DescriptionRed powder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications

Tanshindiol C exhibited most powerful cytotoxic effects against tested tumor cells, with IC50 ranging from 0.4 ug/ml in A-549 cells to 2.2 ug/ml in SK-MEL-2 cells and IC50 from 0.3 ug/ml in SK-MEL-2 cells to 0.9 ug/ml in SK-OV-3 cancer cell lines respectively.


The Danshen-warfarin interaction may be mediated via both pharmacodynamic and pharmacokinetic mechanisms. This review does not summarize recent progress, but the effects of Danshen and its active ingredients on the interactions of cytochrome P450 (CYP450) and drug transporters, as well as the analysis of ingredients, and the metabolism and pharmacokinetics that are related to these interactions. Tanshinones play significant roles in the inhibition and induction of several CYP450 isozymes. It can be concluded that precautions should be taken when using Danshen preparations rich in tanshinones for CYP-related herb-drug interactions.

References1. Rapid Communications in Mass Spectrometry, 2006, 20(8), 1266-1280.
2. Natural Products, 2013, 3551-3581.
3. Drug Metabolism and Drug Interactions, 2012, 27(1), 9-18.
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Tanshindiol C
Price(USD)
SizePrice(USD)Discount
5mg$396.005% OFF
10mg$674.008% OFF
25mg$1145.0015% OFF
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