Catalogue number | C257648 |
Chemical name | Tandutinib |
CAS Number | 387867-13-2 |
Synonyms | 4-[6-Methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-methylethoxy)phenyl]-1-piperazinecarboxamide; CT 53518; MLN 518; |
Molecular Weight | C31H42N6O4 |
Formula | 562.7 |
Purity | 98% |
Physical Description | White Solid |
Solvent | Chloroform, Dichloromethane,DMSO |
Storage | Stored at 2-8°C, Protected from air and light, refrigerate or freeze |
Applications | An oral, small-molecule inhibitor of FLT3 for the treatment of AML (acute myelogenous leukemia) and other cancer indications. The drug exhibited limited activity as a single agent in phase I and II clinical trials in patients with AML and myelodysplastic syndrome, but displayed promising antileukemic activity (90% complete remissions) in a phase I/II trial in patients with newly diagnosed AML when administered in combination with cytarabine and daunorubicin. |
References | Manning, G., et al.: Science, 298, 1912 (2002), Lombardo, L., et al.: J. Med. Chem., 47, 6658 (2004), Knight, Z., et al.: Chem. Biol., 12, 621 (2005), Baselga, J., et al.: Science, 312, 1175 (2006), Garber, K., et al.: Nat. Biotechnol., 24, 127 (2006), Flaherty, K., et al.: Clin. Cancer Res., 13, 747 (2007), |
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50mg | $65.00 | 10% OFF |
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To place an order, please provide the following information.
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2) Purchase order number
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Sent to your order to our email: info@coompo.com
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