TPCA-1

Catalogue number C259584
Chemical nameTPCA-1
CAS Number507475-17-4
Synonyms2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide; 5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxylic acid amide; IKK 2 Inhibitor IV; TPCA 1
Molecular WeightC12H10FN3O2S
Formula279.29
Purity98%
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsTPCA-1 is a direct dual inhibitor for both IKKβ (IKK-2) and STAT3. It inhibits STAT3 phosphorylation, DNA binding, and transactivation in vivo. Synergistic treatment of TPCA-1 with tyrosine kinase inhibitors (TKIs) can potentially be a more effective method for treating cancers.
ReferencesNan, J., et al.: Mol. Cancer Ther., 13, 617 (2014); Birrell, M.A., et al.: Am. J. Respir. Crit. Care Med., 172, 962 (2005); Birrell, M.A., et al.: Mol. Pharmacol., 69, 1791 (2006)
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TPCA-1
Price(USD)
SizePrice(USD)Discount
500µ$50.0010% OFF
g10% OFF
5mg$95.0010% OFF
50mg$595.0010% OFF
1mg$65.0010% OFF
10mg$135.0010% OFF
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