TH-302

Catalogue number C263167
Chemical nameTH-302
CAS Number918633-87-1
SynonymsN,N’-Bis(2-bromoethyl)phosphorodiamidic Acid (1-Methyl-2-nitro-1H-imidazol-5-yl)methyl Ester;
Molecular WeightC8H16Br2N5O4P
Formula449.04
Purity98%
Physical DescriptionOff-White to Pale Yellow Solid
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsTH-302 is a 2-nitroimidazole triggered hypoxia-activated prodrug (HAP) of bromo-isophosphoramide mustard. Studies have shown that TH-302 treatment exhibited hypoxia-selective cytotoxicity and DNA damage in human cancer cell
ReferencesMeng, F. et al.: Mol. Cancer Ther., 11, 740 (2012); Liu, Q. et al.: Cancer Chemother. Pharmacol., 69, 1487 (2012); Sun, J.D. et al.: Clin. Cancer Res., 18, 758 (2012);
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TH-302
Price(USD)
SizePrice(USD)Discount
5mg$250.0010% OFF
50mg$1000.0010% OFF
10mg$350.0010% OFF
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