Catalogue number | C257599 |
Chemical name | TAK-960-d3 |
CAS Number | N/A |
Synonyms | 4-[(9-Cyclopentyl-7,7-difluoro-6,7,8,9-tetrahydro-5-methyl-6-oxo-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-2-fluoro-5-methoxy-N-(1-methyl-4-piperidinyl)benzamide-d3; |
Molecular Weight | CH31D3F3N7O3 |
Formula | 564.62 |
Purity | 98% |
Physical Description | Powder |
Solvent | Chloroform, Dichloromethane,DMSO |
Storage | Stored at 2-8°C, Protected from air and light, refrigerate or freeze |
Applications | Isotope labelled TAK-960 is a potent and selective inhibitor of polo-like kinase 1 (PLK1), a serine/threonine protein kinase involved in key processes during mitosis. TAK-960 has shown activity in several tumor cell lines, including those that express multidrug-resistant protein 1 (MDR1). TAK-960 treatments has shown significant efficacy against multiple tumor xenografts and is a potential chemotherapeutic agent for patients with advanced tumors. |
References | Hikichi, Y. et al.: Mol. Cancer Ther., 11, 700 (2012); Chen, S. et al.: Bioorg. Med, Chem. Lett., 22, 1247 (2012); |
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After Receiving
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10mg | $1800.00 | 10% OFF |
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Sent to your order to our email: info@coompo.com
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