Catalogue number | C100690 |
Chemical name | Strictosamide |
CAS Number | 23141-25-5 |
Synonyms | Strictosidine lactam |
Molecular Weight | C26H30N2O8 |
Formula | 498.5 |
Purity | 98% |
Physical Description | Powder |
Solvent | Chloroform, Dichloromethane,DMSO |
Storage | Stored at 2-8°C, Protected from air and light, refrigerate or freeze |
Applications | The in vitro effects of various concentrations of strictosamide (0.25, 0.5, 1 or 2 mg/mL) and the in vivo effects of single doses (50, 100 or 200 mg/kg, i.p.) of this compound on kidney and brain Na+,K+-ATPase and Mg2+-ATPase activities. Results of general study showed that strictosamide is slightly toxic to Charles River mouse (LD50 = 723.17 mg/kg), producing CNS depression and kidney toxicity, but the exact mechanism of these effects could not be defined. Strictosamide inhibited the in vitro and in vivo Mg2+-ATPase activity on kidney but had nonsignificant effect on brain. Furthermore, strictosamide had nonsignificant in vitro and in vivo effect on kidney Na+,K+-ATPase activity but produced an in vivo increase of Na+,K+-ATPase activity of brain, these findings suggesting that strictosamine may be related to the induction of α2 isoform of Na+,K+-ATPase. |
References | 1. J.C.S.(C), 1969, 1193. 2. Chem. Comm., 1971, 905. 3. Chem. Pharm. Bull., 1997, 45, 1231-1233. 4. J. Am. Chem. Soc., 1979, 101(12), 3358-3369. 5. Journal of Ethnopharmacology, 2009, 121(1), 117-122. |
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After Receiving
The packaging of the product may have turned upside down during transportation, resulting in the product adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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To place an order, please provide the following information.
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Sent to your order to our email: info@coompo.com
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