Strictosamide

Catalogue number C100690
Chemical nameStrictosamide
CAS Number23141-25-5
SynonymsStrictosidine lactam
Molecular WeightC26H30N2O8
Formula498.5
Purity98%
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsThe in vitro effects of various concentrations of strictosamide (0.25, 0.5, 1 or 2 mg/mL) and the in vivo effects of single doses (50, 100 or 200 mg/kg, i.p.) of this compound on kidney and brain Na+,K+-ATPase and Mg2+-ATPase activities. Results of general study showed that strictosamide is slightly toxic to Charles River mouse (LD50 = 723.17 mg/kg), producing CNS depression and kidney toxicity, but the exact mechanism of these effects could not be defined. Strictosamide inhibited the in vitro and in vivo Mg2+-ATPase activity on kidney but had nonsignificant effect on brain. Furthermore, strictosamide had nonsignificant in vitro and in vivo effect on kidney Na+,K+-ATPase activity but produced an in vivo increase of Na+,K+-ATPase activity of brain, these findings suggesting that strictosamine may be related to the induction of α2 isoform of Na+,K+-ATPase.
References1. J.C.S.(C), 1969, 1193.
2. Chem. Comm., 1971, 905.
3. Chem. Pharm. Bull., 1997, 45, 1231-1233.
4. J. Am. Chem. Soc., 1979, 101(12), 3358-3369.
5. Journal of Ethnopharmacology, 2009, 121(1), 117-122.
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Strictosamide
Price(USD)
SizePrice(USD)Discount
5mgInquiryN/A
10mgInquiryN/A
25mgInquiryN/A
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