Coompo Research Chemicals

Gypenosides (Gyp), components of Gynostemma pentaphyllum Makino, were found to induce suppression of human tongue squamous cell carcinoma SCC4 cell growth and induce apoptosis in response to overexpression of reactive oxygen species, calcium (Ca+2) and to decrease mitochondrial membrane potential in vitro. In this study, the effect of Gyp on cell migration and invasion of human tongue SCC4 cells was examined. SCC4 cells treated in vitro with Gyp migrated and invaded less than cells treated with phosphate-buffered saline (PBS) as a control. Gyp inhibited migration and invasion by down-regulating the production of RAS, NFÎB, COX2, ERK1/2 and MMP-9 relative to PBS only. These results show that Gyp inhibits invasion and migration of human tongue SCC4 cells by down-regulating proteins associated with these processes, resulting in reduced metastasis.
The result of the study indicates that Gypenoside can suppress the rise of serum cholesterol (CHO) and triglyceride (TRIG) in hyperlipidaemia mice and lower the content of CHO, TRIG and LDL in hyperlipidaemia quails. The study also shows that Gypenoside has a protective effect on diffuse lipoidosis in liver and atherosclerosis in hyperlipidaemia quails, and that Gypenoside can lower the lipoprotein levels in hyperlipidaemia animals.

The positive inotrope effect and the inhibition of CNS by Gypenoside are related to the in hibitory action of Gypenoside on the actiyily of Na+, K(+)-ATPase from hearts or brains.