Stauprimide

Catalogue number C256932
Chemical nameStauprimide
CAS Number154589-96-5
SynonymsN-[(9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1,3-dioxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3’,2’,1’-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methylbenzamide; N-Benzoyl-7-oxostaurosporine;
Molecular WeightC35H28N4O5
Formula584.62
Purity98%
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsStauprimide is an enhancer stem cell differentiation into endoderm. In vitro differentiation of embryonic stem cells is of great interest to regenerative medicine, and current protocols are labor-intensive and expensive. Small molecules that induce or enhance differentiation are highly desired. High-content screening identified compounds that enhance endodermal differentiation in the presence of low levels of Activin A. Stauprimide increased definitive endodermal markers but not markers for visceral/parietal endoderm or mesoderm. Stauprimide-differentiated cells could be further differentiated into hepatocytes. Stauprimide treatment during differentiation decreased the concentration of Activin A required for definitive endoderm formation, and it eliminated the need for serum. The mechanism
ReferencesJi, L., et al.: J. Biol. Chem., 270, 13392 (1995), D’Amour, K., et al.: Nat. Biotechnol., 23, 1534 (2005), Eastham, A., et al.: Cancer Res., 67, 11254 (2007); S. Zhu et al.: Cell Stem Cell 4, 416 (2009); K.S. Zaret: Cell Stem Cell 4, 373 (2009)
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Stauprimide
Price(USD)
SizePrice(USD)Discount
5mg$250.0010% OFF
50mg$2000.0010% OFF
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