Catalogue number | C108543 |
Chemical name | Saikosaponin B1 |
CAS Number | 58558-08-0 |
Synonyms | (2S,3R,4S,5S,6R)-2-[[(2R,3R,4S,5S,6R)-2-[[(3S,4R,4aR,6aR,6bS,8S,8aS,14bS)-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4a,5,6,7,8,9,10,12,14a-dodecahydropicen-3-yl]oxy]-3,5-dihydroxy-6-(hydroxymethyl)-4-oxanyl]oxy]-6-methyloxane-3 |
Molecular Weight | C42H68O13 |
Formula | 780.9 |
Purity | 98% |
Physical Description | Powder |
Solvent | Chloroform, Dichloromethane,DMSO |
Storage | Stored at 2-8°C, Protected from air and light, refrigerate or freeze |
Applications | Saikosaponin A, B1 and D potently stimulated PGE2 release, while saikosaponin B2 and C moderately stimulated PGE2 release. Saikosaponin B1 caused an irreversible elevation of intracellular Ca2+ concentration, which was eliminated by removing extracellular Ca2+. On the other hand, baicalein inhibited saikosaponin B1-induced PGE2 release in a concentration-dependent manner. These results suggest that saikosaponins are activators of PGE2 release, and baicalein is one of the functional inhibitors of PGE2 release by saikosaponins. |
References | 1. Phytochemistry, 1996, 42(6), 1673-1675. 2. Phytochemistry, 1996, 41(3), 895-901. 3. Anal. Chem., 2004, 76(14), 4208-4216. 4. Bioorganic & Medicinal Chemistry Letters, 1997, 7(17), 2193-2198. 5. Biological & Pharmaceutical Bulletin, 1999, 22(12), 1385-1387. |
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After Receiving
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