SB-505124

Catalogue number C256160
Chemical nameSB-505124
CAS Number694433-59-5
Synonyms2-[5-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)-1H-imidazol-4-yl]-6-methylpyridine;
Molecular WeightC20H21N3O2
FormulaNo Data Available
Purity98%
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsSB-505124 is a selective inhibitor of transforming growth factor-beta type I receptor ALK5 and as well as being a selective inhibitor of ALK4 but with less potency. SB-505124 blocks TGF-β–induced apoptosis of FaO cells and NRP 154 cells in a concentration-dependent manner. SB-505124 has been shown to suppress the migration and invasion of breast cancer MCF-7-M5 cells.
ReferencesGoto, N. et al.: Cancer Sci., 102, 1501 (2011); DaCosta, B.S. et al.: Mol Pharmacol., 65, 744 (2004);
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SB-505124
Price(USD)
SizePrice(USD)Discount
10mg$150.0010% OFF
100mg$1050.0010% OFF
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