Coompo Research Chemicals

Rotundine at 20 mg/kg given subcutaneously (s.c.), which by itself did not produce any antinociceptive effect, significantly inhibited the development of tolerance. The physical dependence was evaluated in male rats. The behavioral signs including jumping, wet-dog shakes, teeth chattering, writhing, diarrhea, ptosis and vocalizing on touch, were observed. Withdrawal was precipitated by a single injection of naloxone in dependent rats. Rotundine (20 mg/kg, s.c.) suppressed jumping, teeth chattering, diarrhea and irritability but not other signs of physical dependence in the rat. The psychic dependence was assessed by the conditioned place preference in male mice. Rotundine (20 mg/kg s.c.), significantly attenuated the place preference induced by morphine. The results suggest that rotundine may be a useful drug for suppressing morphine tolerance and withdrawal symptoms.

Rotundine has significant effect of analgesia at 15min (P=0.022<0.05) and at 30min (P=0.022<0.05). It is ineffective in 60min.Rotundine is used for producing tranquilliser with safe sleeping effect and without side-effects.