Roscovitine

Catalogue number C255846
Chemical nameRoscovitine
CAS Number186692-46-6
Synonyms(2R)-2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol; (R)-2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol; 2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine; CYC 202; (R)-Roscovi
Molecular WeightC18H26N6O
Formula354.45
Purity98%
Physical DescriptionWhite Solid
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsRoscovitine is a potent and selective inhibitor of cyclin-dependent kinases (CDKs). Roscovitine has been found to produce apoptosis in treated cancerous cells of non-small cell lung cancer (NSCLC) and other cancers. Studies show that Roscovitine displays increased anti-mitotic activity at the G1/S and G2/M phases of the cell cycle. Roscovitine maybe useful in the treatment of non-small cell lung cancer (NSCLC), leukemia, HIV infection, herpes simplex infection, and the mechanisms of chronic inflammation disorders.
ReferencesDe Azevedo, W.F. et al.: Eur. J. Biochem., 43, 518 (1997); Planchais, S. et al.: Plant J., 12, 191 (1997); Mgbonyebi O.P. et al.: Anticancer Res., 18, 751 (1998); MacCallum, D.E. et al.: Cancer Res., 65, 5399 (2005);
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Roscovitine
Price(USD)
SizePrice(USD)Discount
500µ$45.0010% OFF
g10% OFF
5mg$85.0010% OFF
25mg$175.0010% OFF
1mg$50.0010% OFF
10mg$125.0010% OFF
50mg$325.0010% OFF
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