Rhein

Catalogue number C108573
Chemical nameRhein
CAS Number478-43-3
Synonyms4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid
Molecular WeightC15H8O6
Formula284.2
Purity98%
Physical DescriptionYellow cryst.
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications

Rhein, also known as cassic acid, is a substance in the anthraquinone group.
Rhein has been reevaluated as an antibacterial agent against Staphylococcus aureus in 2008. Synergy or partial synergy has been demonstrated between rhein and the antibiotics oxacillin and ampicillin.


The pharmacokinetics of rhein have not been intensively studied in humans, but at least one study in healthy male volunteers found that rhein was better absorbed from oral administration of rhubarb than from a retention enema. Rhein (at an oral dose of 50 mg twice per day) was shown to be safe when administered for five days to elderly patients with chronic congestive heart failure.

References1. Journal of Chromatography A, 2003, 1017, 125-130.
2. Magnetic Resonance in Chemistry, 1992, 30(4), 359-360.
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Rhein
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