RAF 265

Catalogue number C255167
Chemical nameRAF 265
CAS Number927880-90-8
SynonymsCHIR 265; 1-Methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine
Molecular WeightC24H16F6N6O
Formula518.41
Purity98%
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsRAF 265 is a multikinase inhibitor that has displayed BRAF inhibiting activity in clinical trials. It could be used in the treatment of a subpopulation of human melanoma tumors. Has cytotoxic effect of on MDA-MB-231 cells. RAF265 when used with BEZ-235 inhibited ERK, PI3K signaling that reduced growth, proliferation and development of drug resistance in human thyroid cancer cells.
ReferencesSu, Y. et al.: Clin. Cancer. Res., 18, 2184 (2012); Zambon, A. et al.: Bioorg. Med. Chem. Lett., 22, 789 (2012); Dittmer, A. et al.: Int. J. Oncol., 39, 689 (2011); Jin, N. et al.: Clin. Cancer. Res., 17, 6482 (2011)
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RAF 265
Price(USD)
SizePrice(USD)Discount
5mg$150.0010% OFF
25mg$480.0010% OFF
10mg$240.0010% OFF
100mg$1440.0010% OFF
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