Coompo Research Chemicals

To discuss influence of protopanaxdiol to interstitial microvascular density and proliferation activity of liver cancer. To construct liver cancer animal models and the experimental animals are divided into five groups, each group includes ten animals. That is control group, CTX group, protopanaxdiol 25mg/kg, 50mg/kg, 100mg/kg group. After two weeks, all the experimental animals will be killed, we will determine tumor volume and weight, then deal it into tissue spices for immmunohistochemistry. To compare with control group, in protopanaxdiol groups, tumor interstitial microvascular density is lower, and its proliferation activity also lower, its volume and weight is lower distinguishly. It suggests that protopanaxdiol inhibites tumor interstitial microvascular density and its proliferation activity, finally inhibites tumor growth.

Protopanaxdiol has the effect of anti-tumor through increasing the activity of body immunity,improving the lymphocyte transformation,the activity of NK cells and the contents of IL-2 significantly.

Protopanaxdiol was effective in preventing and healing obesity, fatty liver and hypertriglyceridemia in mice fed with a high-fat diet.