Plerixafor

Catalogue number C255948
Chemical namePlerixafor
CAS Number110078-46-1
Synonyms1,1’-[1,4-Phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane;
Molecular WeightC28H54N8
Formula502.78
Purity98%
Physical DescriptionWhite to Pale Beige Solid
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsPlerixafor is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). This agent was approved on Dec. 15, 2008, as treatment in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin’s lymphoma (NHL) and multiple myeloma (MM).
ReferencesXie, T., et al.: Science, 290, 328 (2000), Leone, D., et al.: J. Pharmacol. Exp. Ther., 305, 1150 (2003), Chigaev, A., et al.: J. Immunol. 178, 6828 (2007), Kiel, M., et al.: Cell Stem Cell, 1, 204 (2007),
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Plerixafor
Price(USD)
SizePrice(USD)Discount
5mg$75.0010% OFF
25mg$250.0010% OFF
100mg$470.0010% OFF
10mg$110.0010% OFF
50mg$350.0010% OFF
250mg$975.0010% OFF
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