PSI-7977-13CD3

Catalogue number C254391
Chemical namePSI-7977-13CD3
CAS NumberN/A
SynonymsIsopropyl(2S)-2-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyl-tetrahydrofuran-2-yl]methoxy-phenoxy-phosphoryl]amino]propanoate-13CD3; N-[[P(S),2’R]-2’-deoxy-2’-fluoro-2’-methyl-P-phenyl-5’-uridylyl]
Molecular WeightC2113CH26D3FN3O8P
Formula533.46
Purity98%
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsPSI-7977-13CD3 is the isotope labelled analog of PSI-7977. PSI-7977 is a prodrug that is metabolized to the active antiviral agent 2’-deoxy-2’-α-fluoro-β-C-methyluridine-5’-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
ReferencesLam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010);
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PSI-7977-13CD3
Price(USD)
SizePrice(USD)Discount
1mg$200.0010% OFF
10mg$1600.0010% OFF
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