| Catalogue number | C251384 |
| Chemical name | PAC-1 |
| CAS Number | 315183-21-2 |
| Synonyms | 4-(Phenylmethyl)-1-piperazineacetic Acid 2-[[2-Hydroxy-3-(2-propen-1-yl)phenyl] methylene]hydrazide; Procaspase Activating Compound 1 |
| Molecular Weight | C23H28N4O2 |
| Formula | 392.49 |
| Purity | 98% |
| Physical Description | Powder |
| Solvent | Chloroform, Dichloromethane,DMSO |
| Storage | Stored at 2-8°C, Protected from air and light, refrigerate or freeze |
| Applications | PAC-1 is a caspase 3 activator. Caspase activation is a key strategy in cancer therapy. Caspase 3 is a key executioner caspase and direct effector of apoptosis. Hallmark of many cancers is the circumvention of signal in the activation of executioner caspases and loss of apoptotic response. EC50 for caspase 3 activation = 0.33 μM and caspase 7= 4.5 μM. The IC50 for apoptosis induction = 0.92 μM. Elevated caspase 3 level in cancerous cell lines and tissues allows PAC-1 to selectively induce apoptosis in tissues. |
| References | Slee, E., et al.: J. Biol. Chem., 276, 7320 (2001), Pop, C., et al.: Biochemistry, 42, 12311 (2003), Li, L., et al.: Science, 305, 1471 (2004), Green, D., et al.: J. Clin. Invest., 115, 2610 (2005), Satoh, T., et al.: Clin. Cancer Res., 15, 3872 (2009), |
| Guestbook |
After Receiving
The packaging of the product may have turned upside down during transportation, resulting in the product adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Featured Products
| C108539 | 1,3-Dicaffeoylquinic acid | $182.00/20mg |
| C257649 | Tangeretin | $56.00/20mg |
| C108707 | Wogonoside | $80.00/20mg |
| C101411 | Ganoderol B | $294.00/5mg |
| C218295 | Cyanidol 3-Glucoside | $150.00/20mg |
Price(USD)
| Size | Price(USD) | Discount |
| 5mg | $55.00 | 10% OFF |
| 25 mg | $85.00 | 10% OFF |
| 100 mg | $305.00 | 10% OFF |
| 10 mg | $70.00 | 10% OFF |
| 50 mg | $160.00 | 10% OFF |
| 250 mg | $675.00 | 10% OFF |
Orders by E-mail
Orders can be placed by Emails. All orders received will be shipped in the next day if the stock is available.
To place an order, please provide the following information.
1) Your name and telephone number
2) Purchase order number
3) Product number, package size, description, and quantity
4) Shipping and billing addresses
Sent to your order to our email: info@coompo.com
To place an order, please provide the following information.
1) Your name and telephone number
2) Purchase order number
3) Product number, package size, description, and quantity
4) Shipping and billing addresses
Sent to your order to our email: info@coompo.com
Discount Request
If you have any questions about discounts or dealer discount, please send us a message. We will be glad to help.
