NSC 177223

Catalogue number C249962
Chemical nameNSC 177223
CAS Number36707-00-3
Synonyms4-Amino-5,8-dihydro-5-oxo-8-β-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide; API-1
Molecular WeightC13H15N5O6
Formula337.29
Purity98%
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsNSC 177223 is a Akt/protein kinase B inhibitor. It binds to pleckstrin homologous domain of Akt and blocks Akt membrane translocation. Treatment of cancer cells with NSC 177223 results in inhibition of the kinase activities and induction of cell growth arrest and apoptosis selectively in human cancer cells that harbor constitutively activated Akt.
ReferencesKim, D. et al.: J. Bio. Chem., 285, 8383 (2010)
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NSC 177223
Price(USD)
SizePrice(USD)Discount
5mg$150.0010% OFF
50mg$1075.0010% OFF
10mg$250.0010% OFF
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