NO-Aspirin 1

Catalogue number C249561
Chemical nameNO-Aspirin 1
CAS Number175033-36-0
Synonyms2-Acetyloxybenzoic Acid 3-Nitrooxymethylphenyl Ester; 3-(Nitroxymethyl)phenyl 2-acetoxybenzoate; NCX 4016;
Molecular WeightC16H13NO7
Formula331.28
Purity98%
Physical DescriptionOff-White Solid
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsNO-Aspirin 1 is a hybrid molecule of aspirin and a nitric oxide (NO) donor. It contains an ester linkage, that when cleaved by esterases in the gut, liver, and plasma releases salicylate and an NO-releasing moiety. It also prevents restinosiis, inhibits proliferation of vascular smooth muscle cells, reduces infarct ssize following cardiac ischemia, and exhibits strong chemopreventative effects against colon cancer development.
ReferencesWallace, J.F., et al.: Drug Development Res., 42, 144 (1997), Takeuchi, K, et al.: J. Physiol. Pharmacol., 49, 501 (1998), Bak, A.W., et al.: Life Sci., 62, 367 (1998), Wallace, J.L., et al.: Nature Reviews Drug Discovery, 1, 375 (2002), Chiroli, V., et al.: Eur. J. Med. Chem., 38, 441 (2003)
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NO-Aspirin 1
Price(USD)
SizePrice(USD)Discount
5mg$75.0010% OFF
25mg$140.0010% OFF
100mg$510.0010% OFF
10mg$110.0010% OFF
50mg$265.0010% OFF
250mg$1120.0010% OFF
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