N-α-Tosyl-L-phenylalanylchloromethane

Catalogue number C259566
Chemical nameN-α-Tosyl-L-phenylalanylchloromethane
CAS Number402-71-1
SynonymsL-1-Chloro-3-tosylamidyl-4-phenyl-2-butanone; L-1-Chloro-4-phenyl-3-p-tolylsulfonamidobutan-2-one; L-1-Chloro-4-phenyl-3-toluene-p-sulfonamido-2-butanone; L-1-Tosylamide-2-phenylethylchloromethyl Ketone; L-1-Tosylamido-2-phenylethyl Chloromethyl Ketone; L
Molecular WeightC17H18ClNO3S
Formula351.85
Purity98%
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsN-α-Tosyl-L-phenylalanylchloromethane is a proteinase inhibitors with apoptotic function. Studies have shown that it induces caspase-dependent apoptosis in Epstein-Barr virus (EBV)-transformed human B cell lines with release of pro-apoptotic proteins from mitochondria. It also results in down-regulation of the anti-apoptotic proteins and caspase-dependent cleavage of two anti-apoptotic proteins. It promotes dephosphorylation of p53 on serine residues.
ReferencesJitkaew, S. et al.: J. Bio. Chem., 284, 27827 (2009); Kim, K. et al.: Biochem. Biophys. Res. Comm., 306, 954 (2003); Griscavage, J. et al.: Biochem. Biophys. Res. Comm., 215, 721 (1995)
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N-α-Tosyl-L-phenylalanylchloromethane
Price(USD)
SizePrice(USD)Discount
100mg$45.0010% OFF
500mg$85.0010% OFF
2g$245.0010% OFF
250mg$50.0010% OFF
1g$135.0010% OFF
5g$525.0010% OFF
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