Coompo Research Chemicals

Lyoniresinol was tested in B16F10, cells showed robust anti-melanogenic activity. It caused the downregulation of microphthalmia-associated transcription factor (MITF) and tyrosinase steady state protein expression levels. Flow cytometry analysis of Lyoniresinol-treated cells showed that the latter activates extracellular receptor kinase (ERK) phosphorylation, which causes MITF protein degradation and suppression of tyrosinase activity. Lyoniresinol decreased tyrosinase activity and melanin biosynthesis in B16F10 cells by activating ERK signaling, which downregulated MITF, tyrosinase, but not TRP-1 and TRP-2 protein expression. Contingent to more vigorous in vitro and in vivo experiments, Lyoniresinol can perhaps be incorporated into clinical dermatologic use as a skin lightening agent.

Lyoniresinol suppressed linoleate autooxidation more effective than .ALPHA.-tocopherol at 72hr incubation in the presence of 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH). The antioxidant effect of plum bittern was investigated,and lyoniresinol of its main function component of antioxidant effect was detected.