Kazinol B

Catalogue number C100389
Chemical nameKazinol B
CAS Number99624-27-8
Synonyms5-[(S)-6-(1,1-Dimethyl-allyl)-7-hydroxy-1-benzopyran-2-yl]-3-((E)-3-methyl-but-2-enyl)-4-(3-methyl-but-2-enyl)-benzene-1,2-diol
Molecular WeightC25H28O4
Formula392.5
Purity98%
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications

Pretreatment of neutrophils with phorbol 12-myristate 13-acetate (PMA) or formylmethionyl-leucyl-phenylalanine (fMLP) significantly enhanced the O2*- generation following the subsequent stimulation of cells with kazinol B. Kazinol B significantly stimulated [Ca2+]i elevation in neutrophils, with a lag and slow rate of rise activation profile, and this response was attenuated by a phospholipase C (PLC) inhibitor U73122. Kazinol B also stimulated the inositol bis- and trisphosphate (IP2 and IP3) formation with a 1 min lag time. the kazinol B-induced O2*- generation remained relatively unchanged in cells pretreated with ethanol or a tyrosine kinase inhibitor geniste.


Kazinol B are due to an inhibitory effect on cyclooxygenase.
Kazinol B was identified as the active principle. It inhibits the NO synthesis with an IC50 of 21.6 μM.

References1. Journal of the Korean Society for Applied Biological Chemistry, 2012, 55(5), 587-594.
2. Phytochemistry, 1994, 37(3), 851-853.
3. British Journal of Pharmacology, 1998, 125(3), 517-525.
4. Heterocycles, 1985, 23(11), 2835-2842.
5. J. Nat. Prod., 1996, 59(9), 834-838.
6. Fitoterapia, 2003, 74(4), 350-354.
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Kazinol B
Price(USD)
SizePrice(USD)Discount
5mgInquiryN/A
10mgInquiryN/A
25mgInquiryN/A
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