Isosakuranetin

Catalogue number C103947
Chemical nameIsosakuranetin
CAS Number480-43-3
Synonyms(2S)-5,7-dihydroxy-2-(4-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one
Molecular WeightC16H14O5
Formula286.3
Purity98%
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsIsosakuranetin (ISK) is a plant exudate with known cytotoxic and fungicide properties. When tested on wheat root segments at a concentration of 70μM it inhibited K+ dependent H+ extrusion and net uptake of K+, while leaving the membrane potential (PD) unaltered. Fusicoccin (FC) + ISK treatment resulted in a slight membrane depolarization, while ISK alone did not alter O2 consumption or alternative oxidase activity. ISK did not increase the pyruvate content in incubated root tissues or inhibit Fe2+ uptake. The observed drop in K+ net uptake depended on a decrease in K+ influx into the cell, leading to the suggestion that ISK may act on wheat root segments as an inhibitor of K+ permeation. The lack of proton leakage and membrane disruption by ISK made this compound a weak candidate as a phytoalexin, and suggesting a major role as an allelopathic molecule.
Isosakuranetin produced significant decrease in blood pressure.
References1. Biol. Pharm. Bull., 2000, 23, 1122-1124.
2. Biol. Pharm. Bull., 2009, 32(7), 1244-1250.
3. Phytochemistry, 1997, 46(2), 245-248.
4. Phytochemistry, 1998, 49, 1421-1424.
5. Journal of Chromatography B, 2008, 875(1), 142-147.
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Isosakuranetin
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