Iloprost

Catalogue number C243635
Chemical nameIloprost
CAS Number78919-13-8
Synonyms(5E)-5-[(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyl-1-octen-6-yn-1-yl]-2(1H)-pentalenylidene]pentanoic Acid; (1S,2R,3R,5S)-7-[(E)-4-Carboxybutylidene]-2-[(3S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-bicyclo[3.3.0]octane; Ciloprost; End
Molecular WeightC22H32O4
Formula360.49
Purity98%
Physical DescriptionColourless Oil to Off-White St
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsA synthetic analogue of Prostacyclin (PGI2) used to treat pulmonary arterial hypertension (PAH), scleroderma, Raynaud’s phenomenon and ischemia. It acts through elevation of cAMP by binding to the prostacyclin receptor (IP receptor). Iloprost inhibits the ADP, thrombin, and collagen-induced aggregation of human platelets with an ED50 of about 13 nM. In whole animals, iloprost acts as a vasodilator, hypotensive, antidiuretic, and prolongs bleeding time.
ReferencesZamudio, T.P.: Arch. Cardiol. Mex., 77, 198 (2007); Lai, Y. et al.: Am. J. Resp. Crit. Care Med., 178, 188 (2008); Scorza, R. et al.: J. Rheutamol., 24, 1944 (1997); Melillo, E. et al.: Int. J. Microcircul. Clin. Exp., 15, 60 (1995);
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Iloprost
Price(USD)
SizePrice(USD)Discount
500µ$95.0010% OFF
g10% OFF
2.5mg$420.0010% OFF
10mg$1350.0010% OFF
1mg$175.0010% OFF
5mg$800.0010% OFF
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