| Catalogue number | C242208 |
| Chemical name | I-BET 151 |
| CAS Number | 1300031-49-5 |
| Synonyms | 7-(3,5-Dimethyl-4-isoxazolyl)-1,3-dihydro-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-Imidazo[4,5-c]quinolin-2-one; |
| Molecular Weight | C23H21N5O3 |
| Formula | 415.44 |
| Purity | 98% |
| Physical Description | Off-White Solid |
| Solvent | Chloroform, Dichloromethane,DMSO |
| Storage | Stored at 2-8°C, Protected from air and light, refrigerate or freeze |
| Applications | I-BET 151 is part of a novel series of quinoline isoxazole BET family bromodomain inhibitors, a family of four proteins that selectively bind to aceylated lysine residues in histone. I-BET 151 play key roles in many cellular processes, including anti-inflammatory gene expression, mitosis, and viral/host interaction by controlling the conformation of histone acetylation -dependent chromatin complexes. Studies have shown that I-BET 151 increased ApoA1 expression within the nanomolar range in human hepatic cell line HepG2. The upregulation by I-BET 151 suggested potential anti-inflammatory activities upon administration. |
| References | Seal, J., et al.L Bioorg. Medn. Chem. Letters., 22, 2968 (2012); Mirguet, O., et al.: Bioorg. Medn. Chem. Letters, 22, 2963 (2012); Dawson, M.A., et al.: Nature., 478, 529 (2011); |
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After Receiving
The packaging of the product may have turned upside down during transportation, resulting in the product adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Price(USD)
| Size | Price(USD) | Discount |
| 1mg | $50.00 | 10% OFF |
| 10mg | $150.00 | 10% OFF |
| 50mg | $575.00 | 10% OFF |
| 5mg | $75.00 | 10% OFF |
| 25mg | $350.00 | 10% OFF |
| 100mg | $925.00 | 10% OFF |
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To place an order, please provide the following information.
1) Your name and telephone number
2) Purchase order number
3) Product number, package size, description, and quantity
4) Shipping and billing addresses
Sent to your order to our email: info@coompo.com
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