| Catalogue number | C234702 |
| Chemical name | H-1152 Dihydrochloride |
| CAS Number | 871543-07-6 |
| Synonyms | 5-[[(2S)-Hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-methylisoquinoline Hydrochloride; (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolynyl)sulfonyl]Homopiperazine Dihydrochloride; |
| Molecular Weight | C16H23Cl2N3O2S |
| Formula | 392.34 |
| Purity | 98% |
| Physical Description | White to Off-White Solid |
| Solvent | Chloroform, Dichloromethane,DMSO |
| Storage | Stored at 2-8°C, Protected from air and light, refrigerate or freeze |
| Applications | ROCK Inhibitor. A cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK: Ki=1.6nM). Exhibits a much weaker affinity for other serine/threonine kinases (Ki=630nM for PKA 9.27 mMfor PKC, and 10.1mM for MLCK). Shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate MARCKS (IC50=2.5nM) in NT-2 cells. |
| References | Ikenoya, M., et al.: J. Neurochem., 81, 9 (2002), Sasaki, Y., et al.: Pharmacol. Ther., 93, 225 (2002) |
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After Receiving
The packaging of the product may have turned upside down during transportation, resulting in the product adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Price(USD)
| Size | Price(USD) | Discount |
| 1mg | $85.00 | 10% OFF |
| 5mg | $150.00 | 10% OFF |
| 25mg | $700.00 | 10% OFF |
| 2mg | $110.00 | 10% OFF |
| 10mg | $285.00 | 10% OFF |
| 50mg | $1200.00 | 10% OFF |
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To place an order, please provide the following information.
1) Your name and telephone number
2) Purchase order number
3) Product number, package size, description, and quantity
4) Shipping and billing addresses
Sent to your order to our email: info@coompo.com
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