| Catalogue number |
C108080 |
| Chemical name | Ginkgetin |
| CAS Number | 481-46-9 |
| Synonyms | 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)-1-benzopyran-4-one |
| Molecular Weight | C32H22O10 |
| Formula | 566.5 |
| Purity | 98% |
| Physical Description | Yellow cryst. |
| Solvent | Chloroform, Dichloromethane,DMSO |
| Storage | Stored at 2-8°C, Protected from air and light, refrigerate or freeze |
| Applications | Shows CAMP-phosphodiesterase inhibitory activity.
Ginkgetin was previously reported to be a phospholipase A(2) inhibitor and this compound showed the potent antiarthritic activity in rat adjuvant-induced arthritis as well as analgesic activity. Ginkgetin inhibits COX-2 dependent phases of prostaglandin D(2) (PGD(2)) generation in bone marrow-derived mast cells (BMMC) in a concentration-dependent manner with IC(50) values of 0.75 microM. Western blotting probed with specific anti-COX-2 antibodies showed that the decrease in quantity of the PGD(2) product was accompanied by a decrease in the COX-2 protein level. Ginkgetin has a dual cyclooxygenase-2/5-lipoxygenase inhibitory activity. Furthermore, this compound also inhibited degranulation reaction in a dose dependent manner, with an IC(50) value of 6.52 microM. Therefore, this compound might provide a basis for novel anti-inflammatory agents.
A dose-dependent inhibition was observed with ginkgetin on the growth of OVCAR-3 (human ovarian adenocarcinoma) cells with 50% inhibition occurring at 1.8 μg/mL.
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| References | 1. Indian J. Chem., Sect. B, 1996, 35, 283.
2. Biol. Pharm. Bull., 2005, 28(12), 2181-2184.
3. Planta Med., 2002, 68(4), 316-321.
4. Planta Med., 1999, 65(5), 465-467.
5. J. Nat. Prod., 1997, 60(4), 382-384.
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The packaging of the product may have turned upside down during transportation, resulting in the product adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
| Size | Price(USD) | Discount |
| 5mg | Inquiry | N/A |
| 10mg | Inquiry | N/A |
| 25mg | Inquiry | N/A |
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