Catalogue number | C108415 |
Chemical name | Germacrone |
CAS Number | 6902-91-6 |
Synonyms | 3,7-dimethyl-10-propan-2-ylidene-1-cyclodeca-3,7-dienone |
Molecular Weight | C15H22O |
Formula | 218.3 |
Purity | 98% |
Physical Description | Cryst. |
Solvent | Chloroform, Dichloromethane,DMSO |
Storage | Stored at 2-8°C, Protected from air and light, refrigerate or freeze |
Applications | Germacrone treatment significantly inhibited cell proliferation, increased lactate dehydrogenase (LDH) release, and induced mitochondrial membrane potential (ΔΨm) depolarization in both MCF-7 and MDA-MB-231 cells in a dose-dependent manner. Germacrone induced MDA-MB-231 and MCF-7 cell cycle arrest at the G0/G1 and G2/M phases respectively and induced MDA-MB-231 cell apoptosis. Furthermore, germacrone treatment significantly increased Bok expression and cytochrome c release from mitochondria without affecting Bcl-2, Bcl-xL, Bax, and Bim protein expressions. In addition, germacrone treatment induced caspase-3, 7, 9, PARP cleavage. We concluded that germacrone inhibited the proliferation of breast cancer cell lines by inducing cell cycle arrest and apoptosis through mitochondria-mediated caspase pathway. These results might provide some molecular basis for the anti-tumor activity of Rhizoma curcuma.
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References | 1. Journal of Chromatography A, 2005, 1070, 207-210. 2. Eur. J. Pharmacol., 2011, 667(1-3), 50-55. 3. Eur. J. Pharmacol., 2013, 698(1-3), 95-102. 4. J. Org. Chem., 1979, 44(14), 2575-2578. |
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50mg | $148.00 | 8% OFF |
100mg | $251.00 | 15% OFF |
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