Ganoderiol F

Catalogue number C103985
Chemical nameGanoderiol F
CAS Number114567-47-4
Synonyms(5R,10S,13R,14R,17R)-17-[(2R)-7-hydroxy-6-(hydroxymethyl)hept-5-en-2-yl]-4,4,10,13,14-pentamethyl-1,2,5,6,12,15,16,17-octahydrocyclopenta[a]phenanthren-3-one
Molecular WeightC30H46O3
Formula454.7
Purity98%
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications

Shows cytotoxic and anti-HIV activities.
GanoderiolF induced growth arrest of cancer cell lines HepG2, Huh7 and K562, but exerted much less effect in hepatoma Hep3B cells and normal lung fibroblast MRC5 cells, and no effect on peripheral blood mononuclear cells.


GolF was found to inhibit activity of topoisomerases in vitro, which may contribute to the inhibition of cellular DNA synthesis. Activation of the mitogen-activated protein kinase EKR and up-regulation of cyclin-dependent kinase inhibitor p16 were found in early stages of GolF treatment and were presumed to cause cell-cycle arrest and trigger premature senescence of HepG2 cells. The growth-arrest and senescence induction capability on cancer cells suggest anticancer potential of GolF.

References1. L. B. S. Kardono, et al., J. Nat. Prod., 1991, 54(5): 1360-1367.
2. Agric. Biol. Chem., 1988, 52, 367.
3. Chem. Pharm. Bull., 2000, 48, 1026-1033.
4. Journal of Natural Medicines, 2009, 63(3), 304-310.
5. Life Sciences, 2006, 79(12), 1129–1139.
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Ganoderiol F
Price(USD)
SizePrice(USD)Discount
10mg$704.005% OFF
20mg$1197.008% OFF
50mg$2753.0015% OFF
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