Ganoderic acid H

Catalogue number C104070
Chemical nameGanoderic acid H
CAS Number98665-19-1
Synonyms12-Acetoxy-3-hydroxy-7,11,15,23-tetraoxolanost-8-en-26-oic acid; Ganoderic acid C
Molecular WeightC32H44O9
Formula572.7
Purity98%
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications

Potent antitumour agents.


Ganoderic acid A (GA-A) and Ganoderic acid H (GA-H) mediate their biological effects through the inhibition of transcription factors AP-1 and NF-kappaB, resulting in the down-regulation of expression of Cdk4 and the suppression of secretion of uPA, respectively. Furthermore, the activity of ganoderic acids is linked to the hydroxylation in the position 7 and 15 (GA-A) and 3 (GA-H) in their triterpene lanostane structure.

References

1. Chem. Pharm. Bull., 1985, 33, 2624-2627.
2. Planta Med., 1997, 63, 224-227.
3. Planta Med., 1998, 64, 303-308.
4. Phytochemistry, 1985, 24, 2055-2061.
5. Chem. Pharm. Bull., 1986, 34, 3025-3028.

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Ganoderic acid H
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