Flavokawain B

Catalogue number C104515
Chemical nameFlavokawain B
CAS Number1775-97-9
Synonyms(E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-2-propen-1-one; 2’-Hydroxy-4’,6’-dimethoxychalcone
Molecular WeightC17H16O4
Formula284.3
Purity98%
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications

Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways.


Flavokawain B acts through ROS generation and GADD153 up-regulation to regulate the expression of Bcl-2 family members, thereby inducing mitochondrial dysfunction and apoptosis in HCT116 cells.


A potent anti-inflammatory. Flavokawain B significantly inhibited production of NO and PGE2 in LPS-induced RAW 264.7 cells.


Robust mechanisms for Flavokawain B induction of apoptosis preferentially for hormone-refractory prostate cancer and the potential usefulness of FKB for prevention and treatment of hormone-refractory prostate cancer in an adjuvant setting.

References1. Z. Naturforsch., B, 1963, 18, 370.
2. The FASEB Journal, 2010, 24(12), 4722-4732.
3. Free Radical Biology and Medicine, 2010, 49(2), 214-226.
4. J. Agric. Food Chem., 2009, 57(14), 6060-6065.
5. International Journal of Cancer, 2010, 127(8), 1758-1768.
6. Canadian Journal of Physiology and Pharmacology, 2011, 89(12), 875-883.
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Flavokawain B
Price(USD)
SizePrice(USD)Discount
5mgInquiryN/A
10mgInquiryN/A
25mgInquiryN/A
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