| Catalogue number | C231718 |
| Chemical name | F-Amidine |
| CAS Number | 877617-45-3 |
| Synonyms | N-[(1S)-1-(Aminocarbonyl)-4-[(2-fluoro-1-iminoethyl)amino]butyl]benzamide; |
| Molecular Weight | C14H18FN4O2 |
| Formula | 294.32 |
| Purity | 98% |
| Physical Description | Powder |
| Solvent | Chloroform, Dichloromethane,DMSO |
| Storage | Stored at 2-8°C, Protected from air and light, refrigerate or freeze |
| Applications | An inhibitor of Peptidyl arginine deiminase 4 (PAD4) activity with an IC50 value of 21.6 μM in an in vitro activity assay. It irreversibly inactivates (kinact/KI = 3,000 M-1min-1) PAD4 by covalently modifying an active site cysteine that is important for its catalytic activity. Dysregulated PAD4 activity has been implicated in cancer and rheumatoid arthritis. F-amidine also inhibits PAD1 and PAD3 with IC50 values of 29.5 and 350 μM, respectively. F-amidine is cytotoxic to HL-60, MCF7 and HT-29 cancer cell lines (IC50s = 0.5, 0.5 and 1 μM, respectively). |
| References | Jones, J.E. et al.: Curr. Opin. Drug Discov. Dev., 12, 616 (2009); Hill, J.A. et al.: J. Immunol., 171, 538 (2003); Luo, Y. et al.: Biochemistry, 45, 11727 (2006); Knuckley, B. et al.: Biochemistry, 49, 1 (2010); Slack, J.L. et al.: Cell. Mol. Life Sci., 68, 709 (2011); |
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After Receiving
The packaging of the product may have turned upside down during transportation, resulting in the product adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Price(USD)
| Size | Price(USD) | Discount |
| 2.5mg | $175.00 | 10% OFF |
| 25mg | $1400.00 | 10% OFF |
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To place an order, please provide the following information.
1) Your name and telephone number
2) Purchase order number
3) Product number, package size, description, and quantity
4) Shipping and billing addresses
Sent to your order to our email: info@coompo.com
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