Dolutegravir O-β-D-Glucuronide

Catalogue number C228929
Chemical nameDolutegravir O-β-D-Glucuronide
CAS Number1485692-21-4
Synonyms(4R,12aS)-9-[[[(2,4-Difluorophenyl)methyl]amino]carbonyl]-3,4,6,8,12,12a-hexahydro-4-methyl-6,8-dioxo-2H-pyrido[1’,2’:4,5]pyrazino[2,1-b][1,3]oxazin-7-yl β-D-Glucopyranosiduronic Acid
Molecular WeightC26H27F2N3O11
Formula595.5
Purity98%
Physical DescriptionWhite Solid
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsDolutegravir O-β-D-Glucuronide is a metabolite of Dolutegravir (D528800); a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.
ReferencesKobayashi, M. et al. Antimicrob Agents Chemother., 55, 813 (2011); Garrido, C. et al.: Antiviral, Res., 90, 164 (2011); Lenz, J.C.C. et al.: Exp. Opin. Invest. Drugs, 20, 537 (2011)
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Dolutegravir O-β-D-Glucuronide
Price(USD)
SizePrice(USD)Discount
1mg$140.0010% OFF
10mg$1120.0010% OFF
5mg$625.0010% OFF
25mg$2600.0010% OFF
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