Dimethyloxaloylglycine

Catalogue number C227469
Chemical nameDimethyloxaloylglycine
CAS Number89464-63-1
SynonymsN-[(Methoxycarbonyl)methyl]oxamic Acid Methyl Ester; N-(methoxyoxoacetyl)glycine Methyl Ester; DMOG;
Molecular WeightC6H8NO5
Formula175.14
Purity98%
Physical DescriptionOff-White to Pale Pink Solid
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsDMOG is a cell permeable prolyl-4-hydroxylase inhibitor which upregulates HIF activity. HIF activation stimulates angiogenesis in several different models (1nM). DMOG also inhibits FIH (factor inhibiting HIF), an asparaginyl hydroxylase, which enhances the HIF response. It is active in vivo and attenuates myocardial injury in a rabbit ischemia reperfusion model (20mg/Kg).
ReferencesMilkiewicz, M., et al.: J. Physiol., 560, 21 (2004), Koivunen, P., et al.: J. Biol. Chem., 279, 9899 (2004, Asikainen, T.M., et al.: Free Radic. Biol. Med., 38, 1002 (2005),Asikainen, T.M., et al.: Proc. Natl. Acad. Sci. USA, 102, 10212 (2005), Ockaili, R., et al.: Am. J. Physiol. Heart Circ. Physiol., 289, H522 (2005)
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Dimethyloxaloylglycine
Price(USD)
SizePrice(USD)Discount
10mg$45.0010% OFF
50mg$60.0010% OFF
250mg$250.0010% OFF
25mg$50.0010% OFF
100mg$110.0010% OFF
500mg$475.0010% OFF
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