Dendrobine

Catalogue number C108549
Chemical nameDendrobine
CAS Number2115-91-5
Synonyms(2aS,4aS,5R,6S,7R,7aS,7bR)-decahydro-1,7b-dimethyl-6-(1-methylethyl)-7,5-(Epoxymethano)-1H-cyclopent[cd]indol-9-one; 12-Oxodendrobane; NSC 607862
Molecular WeightC16H25NO2
Formula263.3
Purity98%
Physical DescriptionCryst.
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications

Dendrobine on the electrical activity and on amino acid-induced depolarizations of primary afferent terminals were tested on the frog isolated spinal cord and were compared with those of picrotoxinin and strychnine.


Dendrobine caused a slight hyperpolarization in both dorsal and ventral roots and this hyperpolarization was accompanied by the augmentation of the dorsal root potential and the ventral root potential and reflex.


Dendrobine reduced the dorsal root potential induced by repetitive antidromic stimulation of ventral root as well as diminishing the maximum rate of rise of the dorsal root potential.
Dendrobine has a slight but demonstrable analgesic and antipyretic action-much weaker than that of amidopyrine. It produces moderate hyperglycemia, diminishes cardiac activity in large doses, lowers the blood pressure.

References1. J. Am. Chem. Soc., 1974, 96(13), 4332-4334.
2. Tetrahedron, 2000, 56(32), 5801-5805.
3. J. Am. Chem. Soc., 1978, 100(11), 3599-3601.
4. Tetrahedron, 1971, 27(21), 5157-5162.
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Dendrobine
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