| Catalogue number | C101312 |
| Chemical name | Dehydroabietinol |
| CAS Number | 3772-55-2 |
| Synonyms | (1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthren-1-yl)methanol |
| Molecular Weight | C20H30O |
| Formula | 286.5 |
| Purity | 98% |
| Physical Description | Oil |
| Solvent | Chloroform, Dichloromethane,DMSO |
| Storage | Stored at 2-8°C, Protected from air and light, refrigerate or freeze |
| Applications | Dehydroabietinol was found to inhibit growth of chloroquine-sensitive as well as chloroquine-resistant strains of Plasmodium falciparum cultivated in erythrocytes in vitro (IC 50 26-27 microM). However, erythrocytes exposed to dehydroabietinol were transformed in a dose-dependent manner towards spherostomatocytic forms with concomitant formation of endovesicles, as disclosed by transmission electron microscopy. The erythrocyte shape alterations caused by dehydroabietinol correlated well with its apparent IC50 value. Thus, dehydroabietinol incorporates into the erythrocyte membrane, and since invasion and survival of Plasmodium parasites is known to depend on the function of the erythrocyte membrane, the observed antiplasmodial effect of dehydroabietinol is presumably an indirect effect on the host cell. Because of these findings, microscopic investigations should be generally used to support claims of antimalarial effects of apolar natural products. |
| References | 1. Phytochemistry, 1992, 31, 3949. 2. Phytochemistry, 1994, 35, 1509. 3. Planta Med., 2002, 68(6), 547-549. 4. J. Am. Chem. Soc., 1948, 70 (2), 858-860. |
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After Receiving
The packaging of the product may have turned upside down during transportation, resulting in the product adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Price(USD)
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| 10mg | Inquiry | N/A |
| 25mg | Inquiry | N/A |
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To place an order, please provide the following information.
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Sent to your order to our email: info@coompo.com
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