Darinaparsin

Catalogue number C219193
Chemical nameDarinaparsin
CAS Number69819-86-9
SynonymsN-[S-(Dimethylarsino)-N-L-γ-glutamyl-L-cysteinyl]-glycine; Dimethylarsinic Glutathione; ZIO 101; Zinapar; L-γ-Glutamyl-S-(dimethylarsino)-L-cysteinyl-glycine
Molecular WeightC12H22AsN3O6S
Formula411.31
Purity98%
Physical DescriptionWhite to Off-White Solid
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsDarinaparsin is an arsenic cytotoxin that has been used in pharmacological activities to evaluate the effect on survival an radiosensitivity of tumor cells in vitro under normoxia and hypoxia and in vivo using xenograft models. Darinaparsin has significant and preferential cytotoxic and radiosensitizing effects on solid tumors as compared with normal cells.  Darinaparsin may therefore increase the therapeutic index of radiation therapy and has near term translational potential.
ReferencesTian, J., et al.: Clin. Cancer Res., 18, 3366 (2012); Ning, S., et al.: Int. J. Radiat. Oncol. Biol. Phys., 65, 493 (2006);
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Darinaparsin
Price(USD)
SizePrice(USD)Discount
50mg$150.0010% OFF
500mg$1200.0010% OFF
250mg$695.0010% OFF
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