Danshenol A

Catalogue number C104450
Chemical nameDanshenol A
CAS Number189308-08-5
Synonyms(1R,10S)-10-hydroxy-1,6-dimethyl-10-(2-oxopropyl)-1,10-dihydrophenanthro[1,2-b]furan-11(2H)-one
Molecular WeightC21H20O4
Formula336.4
Purity98%
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications

The constituents of the MeOH extract of Salvia miltiorhiza BUNGE, which showed strong aldose reductase (AR) inhibitory activity, were examined, and two new abietane-type diterpenoids, danshenol A and danshenol B. Danshenol A, the strongest inhibitor, had IC50 of 0.10 microM which is comparable to that of epalrestat in clinical use.


Danshenol A was tested for their antitumor activity in T-24, QGY, K562, Me180 and BIU87 cell lines. It showed inhibited growth of K562 (IC50 = 0.53 ug/mL), T-24 (IC50 = 7.94 ug/mL), QGY (IC50 = 4.65 ug/mL) and Me180 (IC50 = 6.89 ug/mL) cell lines.

References1. Biochem. Syst. Ecol., 1998, 26(7), 797-799.
2. Chemical & Pharmaceutical Bulletin, 1997, 45(8), 1306-1311.
3. Journal of Chromatography A, 2009, 1216(24), 4847-4858.
4. Planta Med., 2006, 72(1), 84-86.
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Danshenol A
Price(USD)
SizePrice(USD)Discount
5mgInquiryN/A
10mgInquiryN/A
25mgInquiryN/A
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