Cyclo(Pro-Trp)

Catalogue number C104022
Chemical nameCyclo(Pro-Trp)
CAS Number67889-75-2
Synonyms
Molecular WeightC16H17N3O2
Formula283.3
Purity98%
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications

The effect of the cyclic dipeptides on the gastrointestinal epithelium was assessed by changes in alkaline phosphatase expression of HT-29 cells. Cyclo(Pro-Trp) and cyclo(Phe-Pro) show broad spectrum antibacterial properties and cyclo(Trp-Pro) and cyclo(Trp-Trp) show broad spectrum antifungal properties. The maturation of the gastrointestinal cells was enhanced by cyclo(Phe-Pro), cyclo(Tyr-Pro), cyclo(Trp-Trp) and cyclo(Trp-Pro). The activity of cyclic dipeptides thus indicates potential application of these compounds as pharmacological agents.


The cyclic dipeptides activate a chromatin switch, which leads to the increase in accessibility of lineage-specific genes for transcription.


Cancer Therapy.

References1. Pharmazie., 1999, 54(10), 772-775.
2. Journal of Pharmacy and Pharmacology, 2000, 52(1), 75-82.
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Cyclo(Pro-Trp)
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