| Catalogue number | C107970 |
| Chemical name | Costunolide |
| CAS Number | 553-21-9 |
| Synonyms | (3aS,6E,10E,11aR)-6,10-dimethyl-3-methylene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2-one |
| Molecular Weight | C15H20O2 |
| Formula | 232.3 |
| Purity | 98% |
| Physical Description | Cryst. |
| Solvent | Chloroform, Dichloromethane,DMSO |
| Storage | Stored at 2-8°C, Protected from air and light, refrigerate or freeze |
| Applications | Costunolide exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells. It showed potent inhibitory effects on the IBMX-induced melanogenesis, in dose-dependent manners, with IC50 values of 3 μg/mL. Costunolide induces the ROS-mediated mitochondrial permeability transition and resultant cytochrome c release. This is the first report on the mechanism of the anti-cancer effect of costunolide. Costunolide (CTN), together with parthenolide (PTN) by its strong inhibition of LPS-induced NF-κB activation. CTN, which showed more potent inhibition than PTN in the NF-κB activation, strongly suppressed nitric oxide (NO) production in LPS-stimulated RAW 264.7 cells. RT-PCR and Western blot analyses demonstrated that CTN suppressed the expression of iNOS mRNA and protein in a dose-dependent manner. CTN also significantly inhibited LPS-induced DNA-binding activity of NF-κB as well as the LPS-induced degradation of IκB-α and -β. Furthermore, CTN inhibited LPS-induced phosphorylation of IκB-α. These findings support that CTN inhibits NO production by down-regulating iNOS expression, at least, in part through the inhibition of IκBs' phosphorylation and degradation, which are essential for the activation of NF-κB. |
| References | 1. Archives of Pharmacal Research, 2010, 33(1), 71-74. 2. Archives of Pharmacal Research, 2008, 31(3), 294-299. 3. Phytochemical Analysis, 2005, 16(2), 104-107. 4. Biological and Pharmaceutical Bulletin, 2001, 24(3), 303-306. 5. Planta Med., 2001, 67(2), 103-107. |
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After Receiving
The packaging of the product may have turned upside down during transportation, resulting in the product adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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| 10mg | Inquiry | N/A |
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To place an order, please provide the following information.
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Sent to your order to our email: info@coompo.com
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