| Catalogue number |
C107915 |
| Chemical name | Corosolic acid |
| CAS Number | 4547-24-4 |
| Synonyms | 2α-Hydroxyursolic acid, Colosolic acid, Corosolic acid, Corsolic acid, Glucosol
(1S,2R,4aS,6aR,6aS,6bR,8aR,10R,11R,12aR,14bS)-10,11-dihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid |
| Molecular Weight | C30H48O4 |
| Formula | 472.7 |
| Purity | 98% |
| Physical Description | Powder |
| Solvent | Chloroform, Dichloromethane,DMSO |
| Storage | Stored at 2-8°C, Protected from air and light, refrigerate or freeze |
| Applications | Corosolic acid has properties that help stem diabetes, kill cancer cells, reduce inflammation and blood pressure, and regulate fat metabolism.
Effect of corosolic acid on postchallenge plasma glucose levels.
Corosolic acid (10 mg/kg) reduced the blood glucose (p<0.05) of KK-Ay mice 4 h after single oral administration when compared with the control group. However, corosolic acid did not change the plasma insulin. The muscle facilitative glucose transporter isoform 4 (GLUT4) translocation from low-density microsomal membrane to plasma membrane was significantly increased in the orally
Corosolic acid significantly inhibited cell viability in both a dose- and a time-dependent manner. Corosolic acid treatment induced S cell-cycle arrest and caused apoptotic death in HeLa cells. We found that Corosolic acid increased in Bax/Bcl-2 ratios by up-regulating Bax expression, disrupted mitochondrial membrane potential and triggered the release of cytochrome c from mitochondria into the cytoplasm. Moreover, Corosolic acid treatment triggered the activation of caspase-8, -9 and -3 in HeLa cells. All these results indicate that Corosolic acid-induced apoptosis is associated with the activation of caspases via a mitochondrial pathway. Taken together, we believe that Corosolic acid could have strong potentials for clinical application in treating human cervix adenocarcinoma and improving cancer Chemotherapy.
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| References | 1. Chem Pharm Bull, 2007, 55(5), 784-788.
2. Cancer Letters, 2009, 284, 229-237.
3. J. Chem. Eng. Data, 2011, 56(5), 2181-2186.
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The packaging of the product may have turned upside down during transportation, resulting in the product adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
| Size | Price(USD) | Discount |
| 5mg | Inquiry | N/A |
| 10mg | Inquiry | N/A |
| 25mg | Inquiry | N/A |
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