Conophylline

Catalogue number C101274
Chemical nameConophylline
CAS Number142741-24-0
SynonymsVinca alkaloid III-121C
Molecular WeightC44H50N4O10
Formula794.9
Purity98%
Physical DescriptionYellow powder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications

Conophylline is also a rather potent biological agent, showing potential for treatment of type 1 diabetes, as well as a possible therapeutic role in pancreatic cancer.
Conophylline are useful in inducing differentiation of pancreatic β cells both in vivo and in vitro.


Conophylline also markedly increased the expression of mRNA for insulin and the number of pancreatic duodenal homeobox-1-positive cells. These effects of conophylline were similar to those of activin A.


Conophylline down-regulates the expression of the TNF-alpha receptors on the cell surface. It was found to inhibit TNF-alpha-induced NF-kappaB activation.

References1. J. Nat. Prod., 1993, 56, 1865.
2. Phytochemistry, 1994, 37, 1737.
3. Phytochemistry, 1995, 40, 953.
4. The International Journal of Biochemistry & Cell Biology, 2006, 38(5-6), 923–930.
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Conophylline
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