Coompo Research Chemicals

Chrysophanol is a member of the anthraquinone family and has multiple pharmacological effects. Chrysophanol effectively attenuated overall clinical scores as well as various pathological markers of colitis. Additionally, chrysophanol inhibited the production of tumor necrosis factor (TNF)-a, interleukin (IL)-6 and the expression of cyclooxygenase (COX)-2 levels induced by LPS. This anti-inflammatory effect of chrysophanol is through suppression of the activation of NF-kB and caspase-1 in LPS-stimulated macrophages. These results provide novel insights into the pharmacological actions of chrysophanol as a potential molecule for use in the treatment of inflammatory diseases.Chrysophanol identified as the metabolite responsible for the antimicrobial activity detected in the root extract of the plant.

Emodin and chrysophanol isolated from marine fungus Aspergillus sp. are attenuating the ethanol-induced cytotoxicity of HepG2/CYP2E1 cells. Moreover, the ethanol-induced cytotoxicity could be attenuated by inhibition of GGT activity and CYP2E1 protein expression and providing increased levels of intracellular GSH. Therefore, it suggests that emodin and chrysophanol may provide a novel strategy for attenuating ethanol-induced liver damage.