| Catalogue number |
C104416 |
| Chemical name | Chebulagic acid |
| CAS Number | 23094-71-5 |
| Synonyms | beta-D-Glucopyranose, cyclic 3,6-(4,4’,5,5’,6,6’-hexahydroxy(1,1’-biphenyl)-2,2’-dicarboxylate) 1-(3,4,5-trihydroxybenzoate), cyclic 2-5:4-1-ester with (5-carboxy-3,4-dihydro-3,7,8-trihydroxy-2-oxo-2H-1-benzopyran-4-yl)butanedioic acid, stereoisomer |
| Molecular Weight | C41H30O27 |
| Formula | 954.7 |
| Purity | 98% |
| Physical Description | Powder |
| Solvent | Chloroform, Dichloromethane,DMSO |
| Storage | Stored at 2-8°C, Protected from air and light, refrigerate or freeze |
| Applications | Shows anti-HIV activity.
Potent DNA topoisomerase inhibitor.
Chebulagic acid, a COX-2 and 5-LOX dual inhibitor isolated from the fruits of Terminalia chebula, induces apoptosis in COLO-205 cells.
Chebulagic acid may be of value as broad-spectrum antivirals for limiting emerging/ recurring viruses known to engage host cell glycosaminoglycans for entry. Further studies testing the efficacy of these tannins in vivo against certain viruses are justified.
The maltose-hydrolysis activity was down-regulated by chebulagic acid, which proved to be a reversible inhibitor of maltase in Caco-2 cells. On the other hand, chebulagic acid showed a weak inhibition of sucrose-hydrolysis activity. Meanwhile, chebulagic acid did not have an obvious influence on intestinal glucose uptake and was not effective on glucose transporters. The results presented here suggest that chebulagic acid from T. chebula can be used to control blood glucose and manage type 2 diabetes, although clinical trials are needed.
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| References | 1. Chem. Pharm. Bull., 1980, 28, 3713.
2. BMC Microbiology, 2013, 13, 187.
3. J.C.S. Perkin 1, 1982, 2535.
4. J. Nat. Prod., 1990, 53, 587.
5. J. Ethnopharmacol., 2009, 124(3), 506-512.
6. Int. J. Mol. Sci., 2012, 13(5), 6320-6333.
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The packaging of the product may have turned upside down during transportation, resulting in the product adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
| Size | Price(USD) | Discount |
| 5mg | Inquiry | N/A |
| 10mg | Inquiry | N/A |
| 25mg | Inquiry | N/A |
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